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The Prostate: Part I – BNP What is situated below a body of water, has four zones and is commonly associated with venial pleasures. No it is not some romantic European city, but rather a walnut sized male organ that serves important procreative functions. It also happens to be an organ that plagues men as we age. This organ or gland is the prostate. This is the first of two articles on the male prostate. This article will focus on a disease process that affects older men, something we refer to as benign prostatic hyperplasia (BPH). BPH is a non-cancerous growth in the size of the prostate gland that impairs the flow of urine out of the bladder. The second article will focus of prostate cancer. But first a little about the small yet important male organ. The gland is located just below the bladder. It usually measures one inch by one-and-a-half inches (approximately the size of a walnut). It surrounds the urethra (the tube that takes urine out of the bladder). It is responsible for producing a fluid important in male sexual function. In the past the prostate was described as having “lobes”, but today we refer to it as having concentric zones. These zones are important both on an anatomical as well as histological level. We can separate pathology along these zones as well. For instance most all cancers occur in the peripheral zone while the benign process of enlargement occurs almost exclusively in the transitional zone (which only occupies about 5% of the total prostate volume). The prostate gland is also made up of different cell types. Cancer cells develop from the epithelial cells, but it is the interaction with stromal cells that is important in the behavior of the cancer. BPH develops from an interaction between these cells as well, but it is complex and poorly understood. Testosterone and other hormones and their interactions with this gland are hot topics of research in understanding prostate disease. The prostate gland produces most of what is found in the male ejaculate. The average volume is about 3 mL. This is less than a teaspoon and only 1% of it is sperm. The majority of the semen volume is made of products of the seminal vesicles and the prostate. The male ejaculate is very rich in potassium, zinc, citric acid and fructose. Along with these substances it also contains prostaglandins. There are many other unusual substances found in the semen. Not all is know about their function or purpose. This important male organ is a complex mix of anatomical structures and cell types that make it possible for human reproduction. However beyond the reproductive years of men, this organ becomes one of burden rather than usefulness. We will discuss the finer points of BPH and how to best avoid it and if plagued with it, treatment options. BPH typically affects men from their fourth to fifth decade of life and beyond. Several hormones come into play that have a drastic effect on the transitional zone (the zone that is most central and surrounding the urethra). Namely a metabolite of the male androgen Testosterone called Dihydrotestosterone (DHT) plays a big part on the enlargement of cells of the prostate and the encroachment on the urethra. There are several signs and symptoms that correlate with BPH and they are: slow urinary flow, the urge to urinate all the time, nighttime urination, enlargement and distension of the bladder with continuous urine leakage (incontinence) and urinary obstruction. Autopsies suggest that more than 90% of men older than 70 years have BPH. The average age for symptomatic development is about 65 years for white Americans and about 60 years for African-American men. Ways to prevent the effects of DHT on the prostate gland and the ensuing enlargement are via medications that block the enzyme 5-alpha-reductase, which converts Testosterone to DHT. Proscar is such a drug commercially available through a pharmaceutical company. Proscar works on blocking the effects of androgens on the epithelial cells and can actually shrink the size of the prostate making some of the symptoms of BPH resolve. Alternatively two FDA approved drugs that aid in symptoms of BPH (but act differently than Proscar) are Hytrin and Cardura. Both Hytrin and Cardura are drugs in the alpha1-blocker class. Originally researched as a centrally acting blood pressure reducer for patient with hypertension, it was discovered that this drug would actually relax the prostate tissue surrounding the urethra making symptoms of BPH resolve. Side effects generally include low blood pressure, dizziness, and nasal stuffiness. While neither of these two drugs will “cure” or reverse the process, they certainly do provide symptom relief for the patient plagued with BPH. Another way to treat this disease and a more natural approach is the use of herbs know for their anti-androgenic effects on the prostate. These include the well-studied Saw Palmetto herbal extract that blocks 5-alpha-reductase in the same manner as the prescription drug. Saw Palmetto taken in a standardized dose of 160mg twice daily has shown increased urine flow, with minimal side effects. Saw Palmetto is an herb indigenous to the Lowcountry of Georgia and South Carolina. Pygeum Africanum is shown to do the same yet it is not as effective and there is a fair degree of stomach symptoms. Pygeum is derived from an African evergreen tree. Stinging Nettles (Radix urticae) is another herb used widely in Europe for prostate health that has been shown to lower the residual urine volume in men with enlarged prostates. These phytotherapeutics (plant derived medicines), used and described by the Egyptians as far back as the 15 Century B.C., have a common compounds called phytosterols. The most effective phytosterol is beta sito sterol for BPH. None of the medications or herbs has been shown to prevent prostate cancer. These prescription medications and herbs are for the treatment, reduction in size or prevention of the benign process of enlargement of the prostate. Prostate cancer prevention and treatment is by other means and the subject of the next article. Besides the herbal and drug therapies there are a few surgical therapies worth mentioning. These include the most common transurethral resection of the prostate or TURP. This is where under the care of an urologist the constricted urethra within the prostate gland is “reamed out” thus mechanically or surgically widened the opening. A variant of this is the transurethral incision of the prostate (TUIP) where an incision rather than resection of the tissue is performed. A suitable procedure for patients with prostates 100 mL in volume. This involves an abdominal operation and removal of the whole prostate. Of course symptoms mentioned above for TURP are of greater frequency with this more radical procedure. There is also thermotherapy (a type of microwave treatment) that alleviates irritative symptoms, but not much is available in long-term results in the medical literature. And finally stent placement is an option. This can be used in selected cases of patients with a poor general condition and in the non-operative candidate. Symptoms of BPH include: Obstructive symptoms: Hesitancy in initiating voiding (trouble getting started) Weak urinary stream, prolonged voiding Post-voiding dribbling (mild incontinence) Sensation of incomplete emptying Nocturia (night time urination) Overflow incontinence Acute urinary retention (very painful condition) Irritative symptoms: Dysuria (discomfort in urination) Frequency Urgency Scoring BPH: The American Urological Association Symptom Index (AUASI) and International Prostate Symptom Score (IPSS) are now considered the gold standard measurement tools for the assessment of BPH symptoms and response to treatment. Both questionnaires can be used by a physician in a clinical practice to quantify the subjective symptoms of BPH and monitor therapies. Part II in this series will cover annual examination of the prostate, blood testing, prostate cancer. It will also cover prevention and treatment of prostate cancer. Reference: http://www.prostatehealth.com Lowe, FC. Et al, Phytotherapy in treatment of benign prostatic hyperplasia: a critical review. Urology 48:12-19, 1996 Dreikorn, K. et al, Stellenwert von Phytotherapeutica dei der Behandulng der benighnen Prostatahyperplasia. Urologe (A)34:119-129, 1995 Fitzpatrick, J.M. et al, Phytotherapeutic Agents in Management of Symptomatic Benign Prostatic Hyperplasia. Urological Clinics of North America. 22:407-412, 1995 Wilt T, Ishani A, Mac Donald R.. Serenoa repens for benign prostatic hyperplasia. The Cochrane Database of Systematic Reviews 2002, Issue 3. Art. No.: CD001423. DOI: 10.1002/14651858.CD001423. [Research by Sagalowski and Wilson, 1998] © 2005 penis elargement herb penile girth enlargment enlargement forum free matter penis size free penis enargement exercise penile enlargment result penis enhancement exercise vimax homemade penis enlargement cheap vigrx pills

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Plant base Propecia Biostim is Propecia but without the side-effects. The most common form of hair loss is genetic. Androgenetic alopecia occurs in approximately 60% of men and 10% of women in the U.K. However, if you are a sufferer you do not have to simply live with it as your parents and grandparents may have had to. You can take an active step today and discover Biostim, the new, highly effective hair loss stabiliser and hair regrowth stimulant available directly from our laboratories. Genetic Hair Loss In men, androgenetic alopecia has a characteristic pattern of hair loss it begins with a slight recession at the front hairline and is followed by thinning on the crown of the head. In women, androgenetic alopecia is often linked to hormonal changes with the hair loss following events such as the menopause, childbirth or as a result of stopping or starting oral contraceptive pills. The hair loss is also generally more uniform over the scalp than in the male counterpart. In both sexes, the hair loss results from a complex chemical reaction when the enzyme 5-alpha-reductase converts the testosterone in the system into DHT or dihydrotestosterone. The hair follicles are genetically predisposed to be oversensitive to the DHT and become smaller and smaller with time, leading to the eventual hair loss. How does Biostim work? Biostim is composed of a variety of different ingredients all of which either directly or indirectly benefit hair loss stabilisation and some of which stimulate hair growth. The 11 most important ingredients are as follows: Contents Sabal Serrulata Extract (Biogen) Mono Propylene Glycol Ceramide Panthenol Calcium Panthothenate (Vitamin B3) Vitamin E Vitamin A Vitamin H (Biotin) Vitamin H (P.A.B.A.) Inositol (Vitamin B8) Aqua Description A combination of naturally occurring 5-reductase inhibitors with added multivitamin complex for the stimulation of hair follicles suppressed by the action of Androgens in cases of androgenic alopecia. Mode of Action 5-reductase inhibitors act as anti-androgens, reducing the levels of di-hydroxy testosterone (DHT), decreasing the levels of androgen activity at the target site. The consequent reduced levels of DHT stabilise or reduce the level of atrophy of the hair follicle and shaft in the genetically determined areas in the treatment of androgenic alopecia. The hair growth period (anagen) is prolonged and promotes increased hair growth and density. Clinical Trials Clinical trials of the natural ingredients have established anti-androgen activity and the ability to suppress di-hydroxy testosterone (DHT) formation, beneficial in cases of androgenic alopecia. The increased dermal papilla activity increases hair cell production and proliferation, increases the number of hairs in the anagen phase and increases the A/T (anagen/telogen ration). Biostim has been shown to be a strong inhibitor of 5-alpha reductase in the dermal papilla and to increase hair cell proliferation, particularly on hairs suppressed by androgenic activity. It is believed that the effect of the Biostim is to interfere with the conversion of testosterone to dihydrotestosterone and so there follows a positive response. Biostim is also a good natural source of oestrogen, this may also aid the ‘stimulating’ effect of the plant. Another very important ingredient, which is derived from the vitamin B complex and is a powerful vasodilator, that is to say, it draws the blood to the surface of the skin in the area to which it is applied. The effect of this on the scalp is, firstly, to ‘shock’ any dormant hair follicles from the telogen (resting) phase into the anagen (growing) phase and, secondly, to generally increase the blood supply to the given area, allowing the metabolism to increase and the hair to receive more blood than would normally be the case. Biostim has been formulated with an alcohol compound to carry the active materials to the target site with a minimum of loss into other scalp tissues. Biostim also contains a highly effective anti-dandruff agent that clears the scalp of the dead skin cells and scale that would otherwise absorb much of the lotion and render it less effective. Another major innovation with Biostim is the incorporation of PANTHANOL into the formulation. Panthanol is a natural constituent of healthy hair and so often included in shampoos and conditioners as it has an ability to penetrate into the cortex of the hair to reinforce the chemical bonds and strengthen the hair. The panthanol used in Biostim is not diluted by water as when with shampoos and conditioners and so reaches the hair at the strength at which it is incorporated into the product this is extremely important as the effectiveness of panthanol is directly proportional to the level reaching the cortex and therefore in Biostim it can have an outstanding effect on the strength of the hair. Clinical trials prove that both male and female patients found Biostim reduced hair loss significantly and caused stabilisation within 3 months – all experienced significant hair regrowth between 6 to 12 months. SERENOA REPENS / SAW PALMETTO Serenoa repens is the medical name for the herb saw palmetto. Some studies have shown the saw palmetto may have the same effect as the drug finasteride in treating hair loss and prostate enlargement diseases. It has been suggested that both hair loss and prostate disease are related to the hormone DHT (Dihydrotesterone) which is formed when the enzyme 5-alpha reductase interacts with the male hormone testosterone. Finasteride is marketed as Proscar (5mg finasteride) or propecia (1mg finasteride) by the Merck & Co. Both Proscar and Propecia are oral medication and has been approved by the FDA in the United States. Proscar is usually prescribed for people with benign prostate enlargement. Propecia was approved by the FDA in December 1997 as the first ever anti-baldness pill. Both Proscar and Propecia are available by prescription only. Finasteride works as a 5-alpha reductase inhibitor. It reduces the amount of 5-alpha reductase in our body and thereby reduces the formation of DHT, which is the main cause for hair loss and prostate disease. DHT is formed when 5-alpha reductase interacts with the male hormone testosterone. DHT is a derivate of testosterone but is many times more potent. Hair follicles that are sensitive to DHT tend to fall off when exposed to the hormone. Research has shown that the herb Saw Palmetto has the same effects as finasteride in treating patients with benign prostate enlargement. In fact, the herb is very popular and common in Germany and is available as an over-the-counter medication. There are many studies in Germany that confirm the effectiveness of saw Palmetto in treating patients with prostate disease. Since both hair loss and prostate disease are related to DHT, many suggest that Saw Palmetto will also be effective in treating people with hair loss by reducing the amount of DHT in our body and around the hair follicles. Although there is no formal study or testing to confirm the effectiveness of Saw Palmetto in treating hair loss, many companies are already preparing topical hair lotions that are formulated with saw Palmetto. Since women are CAUTIONED AGAINST using Propecia (1mg finasteride) due to potential side effects that may affect foetus development and cause birth defects, saw palmetto may seem to be a natural alternative for women who are suffering from hair loss. For men who are concerned of the potential side effects of Propecia (1mg finasteride), such as loss of sex drive and impotence as reported by 2% of te participants who took Propecia during clinical testing, saw palmetto is also the natural alternative. There are very few reported side effects of saw Palmetto that have been documented.